(2021) Pegylated multifunctional pH-responsive targeted polymeric micelles for ovarian cancer therapy: synthesis, characterization and pharmacokinetic study. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 1012-1026. ISSN 0091-4037
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Abstract
DTX-loaded folate targeted micelles (DTX/FA-PEG-HEP-CA-TOC) were prepared using a dialysis method and the impact of various processing variables were evaluated on micelle properties.In vitrocytotoxicity andin vivopharmacokinetics of the optimized formulation were evaluated. DTX/FA-PEG-HEP-CA-TOC exhibited average particle size of 90-185 nm with high entrapment efficiency (53-93) and pH-dependent drug release behavior. DTX/FA-PEG-HEP-CA-TOC micelles exhibited higher toxicity against SKOV3 cells than DTX/HEP-CA-TOC micelles and free DTX. Significant increase in theT(1/2)beta, AUC and MRT and decrease inV(d)as well as CL values was observed in DTX/FA-PEG-HEP-CA-TOC micelle treated group compared to free DTX treated group.
| Item Type: | Article |
|---|---|
| Keywords: | Docetaxel heparin ovarian cancer pH-sensitive pharmacokinetics targeted polymeric micelle SELF-ASSEMBLED NANOPARTICLES NANOSTRUCTURED LIPID CARRIERS DRUG-DELIVERY COPOLYMER NANOPARTICLES INTRACELLULAR DELIVERY PULMONARY DELIVERY ALPHA-TOCOPHEROL VIVO EVALUATION IN-VITRO DOCETAXEL |
| Page Range: | pp. 1012-1026 |
| Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Journal Index: | ISI |
| Volume: | 70 |
| Number: | 14 |
| Identification Number: | https://doi.org/10.1080/00914037.2020.1776282 |
| ISSN: | 0091-4037 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/14601 |
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