Evaluation of glomerular filtration rate decline in patients with renal colic

Abstract

Purpose: The aim of current study was to evaluate glomerular filtration rate (GFR) decline in patients with renal colic. Materials and methods: This descriptive analytical study was conducted on patients with definitive diagnosis of renal colic in Alzahra hospital. Data including gender, age, and underlying disease were extracted from medical records. GFR and creatinine level were assessed before and 3 months after stone excretion. Hydronephrosis severity was assessed by ultrasound procedure. Results: In current study, 224 patients with renal colic and mean age 45.6 +/- 11.35 years old were selected. The mean GFR before and 3 months after urinary stone excretion were 45.89 +/- 18.84 and 61.13 +/- 22.10 ml/minute, respectively (P<0.01). The mean creatinine at the beginning and 3 months after urinary stone excretion was 1.93 +/- 0.46 and 1.59 +/- 0.43 mg/dl, respectively (P<0.01). The most frequency of patients with different hydronephrosis degrees was related to score 3 (n=92). There was significant difference between hydronephrosis severity in terms of GFR (P=0.000). No significant difference was seen between the mean GFR at the beginning of the study and at 3 months after urinary stone excretion in terms of diabetes and hypertension (P>0.05). Conclusion: We observed significant difference between hydronephrosis severity in terms of GFR. This indicated that the increase of hydronephrosis degree was associated with worse renal function. Moreover, urinary stone excretion led to the increase of GFR and the decrease of creatinine level. In addition, the mean GFR was not influenced by diabetes and hypertension.