Extraction and Fractionation of the Seaweed Sargassum plagyophylum and Evaluation of Fractions on Depression Induced by Interferon Alpha in Mice

(2022) Extraction and Fractionation of the Seaweed Sargassum plagyophylum and Evaluation of Fractions on Depression Induced by Interferon Alpha in Mice. ADVANCED BIOMEDICAL RESEARCH. ISSN 2277-9175 J9 - ADV BIOMED RES-INDIA

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Abstract

Background: Marine organisms such as seaweeds, produce potent chemicals with characteristic biological features. Sargassum species have great potential to be used for neuronal protection as part of nutraceuticals. The aim was to investigate the effects of hexane and methanol extracts of Sargassum plagyophyhim from the Persian Gulf on depression induced by interferon-alpha (IFNa) in mice. Materials and Methods: S. plagmphylum was extracted by maceration with methanol-ethyl acetate solvent (1: 1). The extract was evaporated and partitioned by hexane and methanol solvents. Male mice were used, depression was induced by SC injecting IFN alpha (16 x 10(-5) (IU)/kg) for 6 days. Animals were subject to the forced swimming test (FST) after the locomotor test, on day 7. The extracts were administered IP either one single dose (acute) before the test, or simultaneously with IFN alpha (sub-acute). Results: The locomotor activity was not different from control values. IFNa increased the immobility time during FST (140 +/- 14 s vs. control group 95 +/- 9 s, P < 0.05). Hexane extract acute (40 mg/kg) injection was not effective while its sub-acute (20 mg/kg) injection reduced immobility time (46 +/- 8 s, P < 0.001 vs. IFNa alone). Methanol extract acute (20 mg/kg) and sub-acute (20 mg/kg) administration significantly reduced immobility during the PST (78 +/- 20 s, and 72 +/- 8 s respectively P < 0.05 vs. IFNa alone). Conclusion: S. plagrophyhtm has antidepressant effects, the hexane extract could prevent depression while the methanol extract not only prevented but also treated depression induced by IFNa in mice. Since this species is abundant in the Persian Gulf further clinical studies on its psychological effects are warranted.

Item Type: Article
Keywords: Depression Interferon-alpha Sargassum plagyophylum seaweed ANTIDEPRESSANT HYPOTHESIS PROMOTES EPILEPSY IDO
Journal or Publication Title: ADVANCED BIOMEDICAL RESEARCH
Journal Index: ISI
Volume: 11
Number: 1
Identification Number: https://doi.org/10.4103/abr.abr₁₈₆₂₁
ISSN: 2277-9175 J9 - ADV BIOMED RES-INDIA
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/15549

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