Effect of curcumin on body mass index and glycemic indices in females with PCOS: a systematic review and meta-analysis of randomized controlled trial

Abstract

Purpose This paper aims to assess the impact of curcumin supplementation body mass index and glycemic indices in women with polycystic ovary syndrome (PCOS). Design/methodology/approach A systematic search of the literature was conducted in PubMed, Scopus and ISI web of science to identify all randomized controlled trials (RCTs) published from the earliest record up to February 2021. The authors used a random-effects model to estimate pooled effect sizes. Findings A total of four potentially related clinical trials met the inclusion criteria which included a total of 198 participants. Random-effects meta-analysis showed significant effects of curcumin on fasting blood sugar (FBS) (-3.62 mg/dl, 95 CI -5.65, -1.58, p-value < 0.001, I-2 = 0.0%), insulin level (-1.67 mu U/mL, 95% CI -3.06, -0.28, p-value = 0.018, I-2 = 0.0%) and homeostasis model of assessment insulin resistance (HOMA-IR) (-0.42, 95% CI -0.76, -0.09, p-value < 0.01, I-2 = 0.0%). No evidence of publication bias was discovered in the meta-analyses. Originality/value Present systematic review and meta-analysis of RCTs showed beneficial effects of curcumin consumption on FBS, insulin level and HOMA-IR in patients with PCOS. However, further large-scale studies are needed to confirm these results.