(2022) EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION: FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE. EXCLI JOURNAL. pp. 840-851. ISSN 1611-2156 J9 - EXCLI J
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Abstract
Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.
| Item Type: | Article |
|---|---|
| Keywords: | Oxidized low density lipoprotein ox-LDL anti-ox-LDL Curcumin Turmeric Curcuma longa OXIDIZED LDL ENDOTHELIAL RECEPTOR CD36 EXPRESSION ANTIOXIDANT MACROPHAGES MECHANISMS CELLS ATHEROSCLEROSIS INFLAMMATION CHOLESTEROL |
| Page Range: | pp. 840-851 |
| Journal or Publication Title: | EXCLI JOURNAL |
| Journal Index: | ISI |
| Volume: | 21 |
| Identification Number: | https://doi.org/10.17179/excli2022-4878 |
| ISSN: | 1611-2156 J9 - EXCLI J |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/16183 |
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