Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences

(2017) Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences. Asian Pacific journal of cancer prevention : APJCP. pp. 295-314. ISSN 2476-762X (Electronic) 1513-7368 (Linking)

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Abstract

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and discussed with suggestions included for future work.

Item Type: Article
Keywords: *Cisplatin *nephrotoxicity *antioxidant *trace elements *herbal agents *gender
Divisions: Faculty of Medicine > Department of Basic Science > Department of Physiology
Water and Electrolytes Research Center
Page Range: pp. 295-314
Journal or Publication Title: Asian Pacific journal of cancer prevention : APJCP
Journal Index: Pubmed
Volume: 18
Number: 2
Identification Number: https://doi.org/10.22034/APJCP.2017.18.2.295
ISSN: 2476-762X (Electronic) 1513-7368 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/1640

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