Evaluation of platelet elevation after injection in patients over 40 years of age admitted hospital; a retrospective study

Abstract

Background: Hemostasis is a hemodynamic process in which the platelet and vessel wall play a major role. Platelet therapy is a standard care for patients with thrombocytopenia. However, some studies reported a progressive decline in platelet elevation after 1, 18, and 24 hours. Methods: In this retrospective study, 35 cases of patients over 40 years of age undergoing platelet injections were enrolled. Blood platelet levels were measured before and after platelet transfusion, and platelet elevation levels were determined according to patients’ demographic and clinical variables. Findings: The average platelet count after platelet injection was significantly higher than the mean before it (P < 0.001). Factors such as gender, splenomegaly, fever, and heparin had significant effect on the changes in platelet count (P < 0.050); but the bleeding factor has no significant effect on it. Conclusion: The incidence of thrombocytopenia and death in patients admitted to intensive care unit is high and should be worrying. Our results indicate that platelet injection is effective in patients requiring it, and may increase platelet levels in these patients after injection. In addition, several factors, such as sex, splenomegaly, fever, and heparin affect platelet levels after injection. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.