(2021) The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia. Blood Sci. pp. 132-135. ISSN 2543-6368
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Abstract
In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25 of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.
| Item Type: | Article |
|---|---|
| Keywords: | Acute myeloid leukemia Dendritic cell Flt3-ITD TIM-3 interest related to the subject matter or materials discussed in this article. |
| Page Range: | pp. 132-135 |
| Journal or Publication Title: | Blood Sci |
| Journal Index: | Pubmed |
| Volume: | 3 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.1097/bs9.0000000000000092 |
| ISSN: | 2543-6368 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/17751 |
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