(2021) T-Cell Molecular Modulation Responses in Atherosclerosis Anergy. Lab Medicine. pp. 557-565. ISSN 00075027 (ISSN)
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Abstract
Atherosclerosis continues to be a major cause of death in patients with cardiovascular diseases. The cooperative role of immunity has been recently considered in atherosclerotic plaque inflammation, especially adaptive immune response by T cells. In this review, we examine the possible role of T cells in atherosclerosis-mediated inflammation and conceivable therapeutic strategies that can ameliorate complications of atherosclerosis. The cytokines secreted by T-lymphocyte subsets, different pathophysiological profiles of microRNAs (miRs), and the growth factor/receptor axis have diverse effects on the inflammatory cycle of atherosclerosis. Manipulation of miRNA expression and prominent growth factor receptors involved in inflammatory cytokine secretion in atherosclerosis can be considered diagnostic biomarkers in the induction of anergy and blockade of atherosclerotic development. This manuscript reviews immunomodulation of T cells responses in atherosclerosis anergy. © American Society for Clinical Pathology 2020
| Item Type: | Article |
|---|---|
| Keywords: | Anergy Atherosclerosis Cholesterol Microrna T-lymphocyte Therapeutic biological marker cytokine epidermal growth factor receptor growth factor growth factor receptor lipoprotein EGFR protein, human cytokine release gene expression human immunomodulation immunopathology inflammation molecular biology nonhuman pathophysiology protein expression protein function Review T lymphocyte T lymphocyte activation T lymphocyte subpopulation clonal anergy disease management disease predisposition genetics immunology metabolism molecularly targeted therapy pathology Biomarkers Cytokines Disease Susceptibility ErbB Receptors Humans Lipoproteins MicroRNAs Molecular Targeted Therapy T-Lymphocytes |
| Page Range: | pp. 557-565 |
| Journal or Publication Title: | Lab Medicine |
| Journal Index: | Scopus |
| Volume: | 51 |
| Number: | 6 |
| Identification Number: | https://doi.org/10.1093/LABMED/LMAA003 |
| ISSN: | 00075027 (ISSN) |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/18111 |
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