Comparison of the effects of remifentanyl-propofol and remifentasnyl-isoflurane on hemodynamic variables, blood gases, and blood glucose among patients under general anesthesia

Abstract

Background: This study aimed to compare the effects of remifentanyl-propofol and remifentasnyl-isoflurane on hemodynamic variables, blood gases, and blood glucose among patients under general anesthesia. Methods: In a clinical trial study, 110 patients under neurosurgeries with general anesthesia were selected and randomly divided in to two groups. Continuing of anesthesia in the first and second groups was done by remifentanyl-propofol and remifentasnyl-isoflurane, respectively. The changes of hemodynamic variables, blood gases, and blood glucose were compared between the two groups. Findings: The mean blood glucose level in the first hour was significantly more in remifentanyl-propofol group (114.3 ± 44.5 mg/dl) compared to remifentasnyl-isoflurane group (94.7 ± 26.9 mg/dl) (P = 0.006); the mean blood glucose levels in the second and third hours were significantly more in remifentanyl-propofol group, too (P < 0.001 for both). In addition, mean blood pressure levels was significantly more in remifentanyl-propofol group (P < 0.050 for all); but blood gases analysis did not show any statistically difference between the groups. Conclusion: Using remifentanyl + isoflurane in patients underwent neurosurgery with general anesthesia led to better blood glucose and blood pressure levels and using this compound is recommended. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.