The effects of systemic prescription of amitriptylineon orthodontic tooth movement rate, root resorption and alveolar bone remodeling in dog

Abstract

Amitriptyline is widely used in the treatment of depression and different types of pain. Since it has anti-inflammatory and antagonist effects on prostaglandin, it can affect the orthodontic treatment. The current inquiry examined the effects of amitriptyline on tooth movement. A case-control experimental study design was conducted. Six male dogs were randomly divided into two experimental and control groups. Amitriptyline(2 mg/kg/day, orally) was prescribed to the experimental group. A nickel titanium spring (200 gr) was used between the second premolar and canine after the 1st premolar extraction. After 2 months, the reduction of distance between the 2nd premolar and canine was measured. The percentages of root resorption and bone formation were determined. The data were analyzed using repeated measures analysis at significance level of 0.05. The average tooth movements were 3.17±0.56 mm in the experimental group and 3.68±0.92 mm in the control group. On the other hand, the average percentages of external root resorption and bone formation in experimental group were 7.97±1.75 and 9.54 ± 1.84, respectively. Moreover, the average percentages of external root resorption and bone formation in control group were 8.33±2.41 and 9.79 ±1.99,respectively. All the differences between two groups were insignificant at the significant level of 0.05. The rate of tooth movement and the percentages of bone formation and root resorption in dogs decreased with systemic administration of amitriptyline although this reduction was not statistically significant in comparison with the control group. This decrease could be related to anti-inflammatory and anti-prostaglandin effects of amitriptyline. © 2017 Oriental Scientific Publishing Company. All rights reserved.