The comparative assessment of vitamin D supplement on glycemic indices in autoimmune diseases

Abstract

Vitamin D deficiency is common among diabetes mellitus and type 2 and multiple sclerosis patients. Type 2 diabetes is recognized by both insulin resistance and beta-cell dysfunction. Vitamin D may treat diabetes according to recommended possible effect of vitamin D on glucose homeostasis. Existing evidence implies a possible connection between disturbed glucose metabolism and MS pathogenesis. The aim of the present study was to compare the effect of complementary vitamin D supplementation on glycemic indices between MS and diabetes type 2 patients. Method: MS and diabetes type 2 patients were divided into 2 groups (group1= 40 patients with MS, group 2= 40 patients with type 2 diabetes mellitus). Both groups were treated by vitamin D injection (300,000 units every 2 weeks for a period of 8 weeks). Glycemic Indies and serum levels of vitamin D were measured and compared before and after the treatment. Results: significant increase in vitamin D levels was seen in both groups particularly in diabetic patients. Significant relationship was found between serum levels of vitamin D and HbA1C in patients with diabetes. There was no relationship between serum levels of vitamin D and lipid profile. Conclusion: vitamin D supplements, is more effective on glycemic indices and serum levels of vitamin. D in patients with Type 2 Diabetes than in MS patients.