Dietary Acid Load and Its Association with Psychological Disorders and the Odds of Disease in Diarrhea-Predominant Irritable Bowel Syndrome: A Case-Control Study

Abstract

Background: This study aimed to investigate the relationship between dietary acid load)DAL(with psychological disorders and the odds of disease in patients with diarrhea-predominant irritable bowel syndrome)IBS-D(. Materials and Methods: This case-control study was performed on 61 patients with IBS-D and 61 healthy matched individuals aged 20 to 55 years in Isfahan. To collect data, 3-day dietary record and Depression, Anxiety and Stress Scale - 21 Items (DASS-21(were used. Also, anthropometric indices were measured. Results: No significant difference was found between potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores between the two groups. There was a significant direct relationship between NEAP scores with stress and depression in the IBS-D group and also with anxiety in the two groups)P<0.05(. No association was found between PRAL and NEAP with odds of IBS-D in both crude and adjusted models. Conclusion: Dietary acid load may be associated with psychological disorders in patients with IBS-D. Further prospective studies are needed to confirm these findings. © 2022 Iranian Association of Gastroenterology and Hepatology. All rights reserved.