The Effect of Hemodialysis of on Serum Troponin I level in Patients with Renal Disease and Normal Left Ventricular Ejection Fraction

Abstract

Background: One of the important criteria for acute myocardial ischemia is the level of troponin. The fact that troponin is excreted by the kidneys, and patients under dialysis may have a high level of it, makes the diagnosis of acute ischemia difficult. The present study aimed to evaluate the effect of hemodialysis on serum troponin I level in patients with end-stage renal disease (ESRD) and normal left ventricular ejection fraction (LVEF). Methods: In this cross-sectional study, 106 patients with ESRD and LVEF of more than 50 who underwent hemodialysis during 2018-2019 in Khorshid and Alzahra hospitals in Isfahan, Iran, were studied. The serum levels of troponin I were measured and compared before and after hemodialysis. -Findings: The mean serum level of troponin I was 0.031 ± 0.068 and 0.028 ± 0.036 ng/dl before and after hemodialysis, respectively, with no statistically difference (P = 0.590). The mean difference of troponin level before and after the hemodialysis was 0.003 ± 0.06 ng/ml. Moreover, the changes of troponin levels were not significantly associated with age, sex, duration of dialysis, hemoglobin and hematocrit levels, LVEF, cause of renal failure, and type of underlying disease. Conclusion: The findings of the present study showed that hemodialysis did not have a significant effect on changes in troponin I levels, and the level of troponin I did not appear to be a suitable biomarker for the expression of cardiovascular disease in hemodialysis patients with normal LVEF. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.