(2022) Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial. Nutrition Journal. ISSN 14752891 (ISSN)
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Abstract
Background: Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calcitonin gene-related peptide (CGRP) levels in women with migraine. Methods: Eighty-three participants completed a randomized double-blind controlled trial, receiving 50 mg per day soy isoflavones or placebo supplementation for 8 weeks. Migraine severity, migraine days per month, frequency and duration of attacks, mental status, quality of life and serum CGRP levels were measured at baseline and the end of the intervention. Bivariate comparison and intention-to-treat (ITT) were used for analysis. Results: Soy isoflavones intake resulted in a significant decrease in mean frequency (-2.36 vs -0.43, P < 0.001), duration (-2.50 vs -0.02, P < 0.001) of migraine attacks and CGRP level (-12.18 ng/l vs -8.62, P = 0.002) in compared to placebo group. Also, a significant improvement was found in quality of life (16.76 vs 2.52, P < 0.001). Although, reduction in the migraine severity and mental status did not reach a statistically significant level (P > 0.05). Conclusion: soy isoflavones supplementation may be considered as a complementary treatment for women with migraine to improve migraine characteristics and reduce the burden of disease. © 2022, The Author(s).
| Item Type: | Article |
|---|---|
| Keywords: | CGRP Headache Migraine Soy Isoflavones benzodiazepine beta adrenergic receptor blocking agent calcitonin gene related peptide gabapentin isoflavone derivative nonsteroid antiinflammatory agent placebo serotonin uptake inhibitor tricyclic antidepressant agent triptan derivative valproic acid adult anxiety disorder Article clinical feature controlled study depression diet supplementation disease duration double blind procedure drug effect female human intention to treat analysis major clinical study mental disease mental health pain severity protein blood level quality of life randomized controlled trial soybean treatment duration women's health dietary supplement treatment outcome Calcitonin Gene-Related Peptide Dietary Supplements Double-Blind Method Humans Isoflavones Migraine Disorders |
| Journal or Publication Title: | Nutrition Journal |
| Journal Index: | Scopus |
| Volume: | 21 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1186/s12937-022-00802-z |
| ISSN: | 14752891 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/24721 |
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