Effects of nanozeolite/starch thermoplastic hydrogels on wound healing

(2017) Effects of nanozeolite/starch thermoplastic hydrogels on wound healing. Journal of Research in Medical Sciences. ISSN 1735-1995

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Abstract

Background: Wound healing is a complex biological process. Some injuries lead to chronic nonhealing ulcers, and healing process is a challenge to both the patient and the medical team. We still look forward an appropriate wound dressing. Materials and Methods: In this study, starch-based nanocomposite hydrogel scaffolds reinforced by zeolite nanoparticles (nZ) were prepared for wound dressing. In addition, a herbal drug (chamomile extract) was added into the matrix to accelerate healing process. To estimate the cytocompatibility of hydrogel dressings, fibroblast mouse cells (L929) were cultured on scaffolds. Then, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide assay test and interaction of cells and scaffolds were evaluated. For evaluating healing process, 48 male rats were randomly divided into four groups of four animals each (16 rats at each step). The ulcers of the first group were treated with the same size of pure hydrogels. The second group received a bandage with the same size of hydrogel/ extract/4 wt nZ (hydrogel NZE). The third group was treated with chamomile extract, and the fourth group was considered as control without taking any medicament. Finally, the dressings were applied on the chronic refractory ulcers of five patients. Results: After successful surface morphology and cytocompatibility tests, the animal study was carried out. There was a significant difference between starch/extract/4 wt nZ and other groups on wound size decrement after day 7 (P < 0.05). At the clinical pilot study step, the refractory ulcers of all five patients were healed without any hypersensitivity reaction. Conclusion: Starch-based hydrogel/ zeolite dressings may be safe and effective for chronic refractory ulcers.

Item Type: Article
Keywords: chamomile hydrogel nanocomposite ulcer wound zeolite drug-release starch antioxidant nanofibers scaffolds extract films
Divisions: Biosensor research center
Faculty of Medicine > Department of Basic Science > Department of Anatomical Sciences
Isfahan Endocrine and Metabolism Research Center
School of Advanced Technologies in Medicine
School of Advanced Technologies in Medicine > Department of Bioelectrics and Biomedical Engineering
Journal or Publication Title: Journal of Research in Medical Sciences
Journal Index: ISI
Volume: 22
Identification Number: Artn 110 10.4103/Jrms.Jrms₁₀₃₇₁₆
ISSN: 1735-1995
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/298

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