Comparison of the Effect of Modified and Conventional Hemofiltration and the Combination of Both Methods During Coronary Artery Bypass Graft Surgery (CABG) on Kidney Function

Abstract

Background: While coronary artery surgery is a particular medical procedure, it can impact other organs, such as the kidneys. As such, this study seeks to compare the effects of hemofiltration, two new and prevalent methods, and a combination of the two methods during cardiopulmonary bypass surgery on kidney function. Methods: This study was a clinical trial that involved 60 patients undergoing cardiopulmonary bypass in the open-heart surgery room of Chamran Hospital, Isfahan. The study utilized a three-arm and double-blind randomized approach with an easy and accessible sampling method. The three intervention methods tested were common ultrafiltration, modified ultrafiltration, and a combination. The data was analyzed with a significance level of 5. Findings: The serum creatinine mean (SD) of patients in the intervention group increased by 1.15 (± 0.20) within the initial 24 hours after surgery, compared to the mean value of 1.02 (± 0.10) before surgery. In the common method, the mean glomerular filtration rate (± standard deviation) decreased in the first 24 hours after surgery compared to its mean value before surgery, which was 66.74 (± 8.95). Conclusion: Changing the method of ultrafiltration has no impact on kidney function. The reduction in 24-hour drainage volume was more effectively achieved through either a novel method alone or a combination of two methods compared to the conventional method alone. © 2025 Isfahan University of Medical Sciences(IUMS). All rights reserved.