The Effect of Different Doses of Labetalol on the Volume of Bleeding During and After Dacryocystorhinostomy Surgery

Abstract

Background: The aim of this study was to determine the effect of different doses of labetalol on the volume of bleeding during dacryocystorhinostomy surgery. Methods: In this clinical trial study, 90 patients who were candidates for dacryocystorhinostomy surgery were randomly divided into 3 groups (1 to 3) and immediately before the operation and if hemodynamics were stable, group 1 received labtalol 0.2 mg/kg, group 2 received labetalol 0.4 mg/kg and the control group received distilled water as a placebo with the same volume via intravenous infusion over 5 minutes. The volume of bleeding and hemodynamic variables were assessed. Data were analyzed using the chi-squared test. Findings: The volume of bleeding during surgery and in recovery in the intervention groups was significantly lower than in the control group (P < 0.05). Additionally, there was no significant difference in intraoperative bleeding volume between the intervention groups during the study. Diastolic and systolic blood pressure and heart rate during the study in the intervention groups at 15 and 30 minutes after the start of surgery were significantly lower than in the control group, but there was no significant difference between the two intervention groups in this regard. Other measured parameters did not differ significantly between groups. Conclusion: The use of labetalol in the intervention groups significantly reduced the volume of intraoperative bleeding during dacryocystorhinostomy, but no significant difference was observed between the 0.2 mg/kg and 0.4 mg/kg doses. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.