Evaluation of the Relation between HB, MCV, MCH, RDW and Severity of Disability and Annual Recurrence of MS in Patients with MS Referred to MS Clinic of Kashani Hospital

Abstract

Background: Multiple sclerosis (MS) is a chronic, inflammatory, immune-mediated disease of the central nervous system (CNS). Although complete blood count (CBC) is known a marker of systematic inflammation, relation between CBC indexes such and MS remains understudied. This study was conducted to assess the association between different CBC findings with demographic and clinical features of MS patients and compare them with healthy control (HC). Methods: This cross-sectional study was conducted in MS clinic of Kashani Hospital. A total of 1764 participants were involved in this study, including 729 (41.3) patients with MS and 1035 (58.7) control was enrolled. CBC counts were obtained via routine blood sampling, as part of the clinical practice. HC recruited from people who visited our Hospital for routine checks-up. Findings: All CBC indexes were significantly associated with MS except for RBC and HCT. We observed higher HB (Est. = 1.407; P < 0.001), HCT (Est. = 3.937; P < 0.001), MCV (Est.=1.482; P = 0.042), MCHC (Est.=0.443; P = 0.011) in male. Patients with autoimmune comorbidity demonstrated less RBC (Est. =-7.440; P < 0.001) and HB (Est. =-2.610; P < 0.001) compared to patients without autoimmune comorbidity. HB (Est. = 1.447; P = 0.025), HCT (Est. = 4.877; P = 0.002), MCV (Est. = 5.670; P = 0.027) were higher in PPMS than RRMS. There was no association between the first EDSS and CBC indexes. Conclusion: Our results showed an association between CBC markers and MS. We found no association between blood indexes and clinical findings. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.