Factors Affecting Thrombocytopenia in Patients with Pesticide Intoxication

Abstract

Objective: This study aimed to investigate the factors affecting the occurrence of thrombocytopenia in patients due to pesticide intoxication. Methods: A cross-sectional study was conducted from 2016 to 2021. Data were collected from patients admitted with acute pesticide poisoning, focusing on demographics, intoxication features, clinical outcomes, and laboratory findings. Patients were classified into three groups based on the day of platelet reduction: first day, second day, and third day onwards. Severity of platelet reduction was measured. Statistical analysis included descriptive statistics, comparative analysis, and logistic regression odd ratio (OR), 95% confidence interval (CI). Results: Of the 235 patients included, the majority were male (76.4%), with insecticides being the most frequent pesticide encountered. All patients had reduced platelet counts, but at different days and severity levels. Higher mortality rates and longer hospital stays were observed in the group with the presentation of thrombocytopenia on the third day or later. When comparing the third day to the first day, the administration of vitamin C medication OR (95% CI), 7.664 (1.093–53.747), p = 0.04 and the use of pantoprazole medication OR (95% CI), 3.08 (1.257–7.543), p = 0.014 were found to impact thrombocytopenia occurrence. Patients who were admitted to the intensive care unit had a 2.6-fold higher probability of developing thrombocytopenia OR (95% CI), 2.635 (1.11–6.25), p = 0.02. There was no significant difference in the odds of more severe thrombocytopenia based on onset timing. Conclusion: This study sheds light on factors associated with the occurrence of thrombocytopenia, emphasizing the need for targeted interventions and further research to improve patient outcomes. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025.