Immune checkpoint inhibitors and IgA nephropathy; A rare side effect

Abstract

The pathophysiological mechanisms of secondary IgA nephropathy (IgAN) containing IgA-mediated immune complex deposition in the glomeruli. However, the specific triggers can vary widely, including infections, liver disease, and malignancies, in addition to drug-induced factors. IgAN is a rare however is a serious complication of immune checkpoint inhibitor (ICI) therapy that can lead to acute kidney injury. Clinically, the diagnosis of sIgAN typically follows a temporal association between medication administration and the onset of renal symptoms, such as hematuria or proteinuria. A kidney biopsy is often necessary to confirm the diagnosis and rule out other causes of nephropathy. Copyright © 2025 The Author(s); Published by Society of Diabetic Nephropathy Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.