Solitary myofibroma of the oral cavity; a rare case report

Abstract

Myofibroma is an uncommon benign neoplasm of myofibroblastic origin that primarily affects children and adolescents. While it most frequently arises in the skin and subcutaneous tissues, its occurrence in the oral cavity, particularly in the buccal soft tissue is exceptionally rare. Owing to its clinical similarity to other benign spindle-cell lesions, such as irritation fibroma and neural tumors, establishing an accurate diagnosis can be challenging. This report describes a rare case of solitary oral myofibroma presenting as a buccal soft tissue swelling of the left mandible. The clinical, radiographic, histopathologic, and immunohistochemical features are presented, together with a discussion on differential diagnosis, management, and prognosis. © 2026 The Author(s); Published by Society of Diabetic Nephropathy Prevention.