The Relationship between Coronary and Venous Sinus Lactate Level Before and After Cardiopulmonary Bypass with Mortality and Postoperative Complications

Abstract

Background: The present study aimed to evaluate the relationship between coronary and venous sinus lactate level before and after cardiopulmonary bypass (CPB) with mortality and postoperative complications. Methods: The present cross-sectional study was conducted on 32 CABG candidate patients referred to Chamran Hospital. Before the start of the operation, after the patients were placed on the surgical bed and venous and arterial lines were established and initial monitoring was performed, arterial and venous blood samples and coronary sinus were taken and lactate levels were examined. After the operation and after admission to the intensive care unit, lactate levels were also measured. Findings: The venous lactate level of patients after CPB was significantly higher with a mean of 2.44 ± 0.47 than before CPB with a mean of 1.64 ± 0.68 (P = 0.006). Also, the coronary sinus lactate level after CPB was significantly higher with a mean of 2.27 ± 0.86 than before CPB with a mean of 1.23 ± 0.95 (P < 0.001). However, the venous and sinus lactate levels of these patients before and after CPB were not significantly different (P > 0.05). In addition, only the duration of hospitalization in the intensive care unit and hospital had a direct and significant relationship with the increase in lactate (venous or coronary sinus) (P < 0.05). Conclusion: According to the results of this study, both venous and coronary sinus lactate levels significantly increased after CPB compared to before. However, the increase in lactate levels was only significantly associated with the duration of hospitalization in the intensive care unit and hospital. © 2026, Isfahan University of Medical Sciences(IUMS). All rights reserved.