Optical Coherence Tomography Angiography Analysis of Changes in the Retina Before and After Hemodialysis in Chronic Renal Failure Patients

Abstract

Background: Hemodialysis can change the hemodynamics of body fluids and its effect on the eye retina. In this study, coherence tomography angiography was performed to evaluate the effect of hemodialysis on retinal parameters of the eye before and after hemodialysis. Methods: This cross-sectional study was performed on 27 patients with chronic renal failure in the dialysis ward of Hajar Hospital in Shahrekord. Inclusion criteria included a history of hemodialysis for at least 1 year and no previous eye disease such as glaucoma, retinopathy, retinal disease or previous eye surgery and exclusion criteria for diabetes. A checklist was used to collect data. Retinal indices were assessed using optical coherence tomography angiography before and after dialysis. Data were analyzed using SPSS24 software. Findings: The indices of retinal thickness and retinal superficial vascular density did not change significantly before and after hemodialysis (P> 0.05). The results of deep retinal vascular density showed that the mean Parafovea Inferior hemisphere change from 49.61 before hemodialysis to 44.22 μm after hemodialysis (P=0.019). The mean of Parafovea temporal from 81.18 μm to 42.95 μm (P=0.05), the mean of Parafovea nasal from 48.23 to 42.86 (P=0.022) and the average Perifovea nasal from 51.43 01m decreased 01/45 (P=021). Conclusion: Given that OCTA is a new imaging technique and the results of studies in this field are limited, the results should be interpreted with caution. Based on the findings of this study, it was concluded that hemodialysis did not significantly change the retinal parameters of patients. © 2026, Isfahan University of Medical Sciences(IUMS). All rights reserved.