Comparative Study of Two Types of Fluid Therapy with Dextrose Saline Serum (DS) and One-Third Two-Thirds Serum (1.3, 2.3) in Patients with Acute Opioids Poisoning in Terms of Outcome and Length of Hospitalization

Abstract

Background: Opioid poisoning is the most common case of hospitalization in the emergency room of poisoned patients. Administering fluid therapy with appropriate serum with the aim of establishing tissue perfusion and electrolyte stability is a crucial step in the therapeutic management of these patients. Methods: This study is cross-sectional and descriptive-analytical. The target population is all patients aged 15 to 64 years with opioid poisoning admitted to the poisoning ward of Khurshid Hospital, Isfahan in 2020-2021. The prepared checklist including demographic variables, vital signs, paraclinical test results and complications, and clinical outcome completed and the study results analyzed. Findings: 169 patients poisoned with various opioid, including 73.3 men, were included in the study. The mean age of the patients was 35+₁₃ years. A significant relationship observed between the treatment outcome, the type of opioid used, DBP, RR on admission and at 24 hours of hospitalization, and CPK on admission, with the type of fluid therapy. No significant relationship was observed between other variables including the first dose of naloxone required, the interval between opioid use and hospital admission, the length of hospital stay, and most tests and vital signs with the type of fluid therapy. Conclusion: No significant difference was identified between treatment outcome, length of hospital stays, vital signs, and laboratory tests in fluid therapy with the serums studied in this study. The selection of maintenance therapy with available fluids should be based on the individual needs of patients and clinical conditions. © 2026, Isfahan University of Medical Sciences(IUMS). All rights reserved.