Comparing the effect of remifentanil, propofol and remifentanil plus propofol on the sedation score among patients under phacoemulsification cataract surgery

Abstract

Background: This study was aimed to determine the effects of remifentanil, propofol and remifentanyle plus propofol on the sedation score among patients under phacoemulsification cataract surgery with local anesthesia and comparison with a control group. Methods: In a clinical trial study in 2015-2016, 140 candidates for cataract surgery with phacoemulsification method randomly divided in four groups of 35 patients. Propofol, remifentanil, propofol plus remifentanil and normal saline was injected during surgery in the groups and sedation score was measured during surgery and compared between the four groups. Findings: Sedation score in the before operation in Propofol, remifentanil, propofol plus remifentanil and normal saline was 3.31 ± 0.87, 4.91 ± 0.28, 2.97 ± 0.75 and 4.97 ± 0.30, respectively (P < 0.001). Also sedation score at 30th min was 2.00 ± 0.01, 3.40 ± 0.55, 2.10 ± 1.00 and 3.00 ± 0.01, respectively (P = 0.110). The mean changes of the sedation score in the four groups were different (P < 0.001). Conclusion: Using remifentanil plus propofol in patients under phacoemulsification cataract surgery led to better sedation during surgery and lower post-operative pain. So, using both the drugs is recommended. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.