Evaluation of prophylactic injection of two doses of tramadol on heart rate and blood pressure changes compared with control group after laryngoscopy and intubation

Abstract

Background: Laryngoscopy is an invasive technique which is associated with severe cardiovascular complications. This study compared the effects of two doses of tramadol hydrochloride (2mg/kg, 1mg/kg) on heart rate and blood pressure with control group after laryngoscopy and intubation in elective surgical patients. Methods: In this clinical trial performed in 2015, 180 candidates in Kashani care center, Isfahan, Iran, were randomly divided to control (no drugs were used), tramadol 1mg/kg and tramadol 2mg/kg groups. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were recorded immediately before, after, and 1, 3 and 5, 10 min after laryngoscopy. Data were analyzed using SPSS and ANOVA and Tukey post hoc tests. Findings: There were significant differences in systolic, diastolic and mean arterial pressure between control group and two doses of tramadol (P < 0.05). Also in heart rate the differences were significant. The incidence of hypertension, tachycardia, hypotension and bradycardia were less in two doses of tramadol. Conclusion: Prescribing 2 mg/kg of tramadol causes more stable blood pressure and heart rate compared with control group. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.