Evaluation of the relationship between serum level of selenium at arrival to intensive care unit with duration of mechanical ventilation, mortality and inflammatory factors in multiple trauma patients

Abstract

Background: Selenium is a trace element in the body that plays multiple physiological roles. Lack of this element can affect many serum mediators and immune cells. Abnormality in serum selenium impairs organ function and eventually causes sepsis and organ failure and reduced survival. Therefore this study was conducted to evaluate the relation between serum selenium level at arrival to intensive care unit with duration of ventilation, inflammatory factors and mortality in multiple trauma patients. Methods: 80 multiple trauma patients hospitalized in intensive care unit (ICU) of Al-Zahra hospital, Isfahan, Iran, aged 16 to 85 years were included. Serum level of selenium, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), Interleukin 1(IL1), IL33, and IL6 were measured. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were calculated for each patient. Pearson’s correlation was used to analysis the relationship between these variables and serum level of selenium. Findings: All 80 patients were included in final analysis. Mean selenium level was 77.54 ± 44.90 and 43 patient (53.8) had low levels of selenium and 37patient (46.2) had normal level. Pearson correlation showed correlation between Serum selenium levels and IL6, ESR, white blood cell (WBC) and mortality, but, there was no significant correlation with other variables. Conclusion: There is no relation between serum level of selenium and mechanical ventilation of multiple trauma patients but there is relation between its level and mortality and some inflammatory factors. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.