(2016) Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: A double-blind placebo-controlled clinical trial. Journal of Complementary and Integrative Medicine. pp. 175-180. ISSN 15533840 (ISSN)
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Abstract
Background: Roselle (Hibiscus sabdariffa L.) is a plant with antihyperlipidemic and antihypertensive effects. This study aimed to evaluate the effects of roselle calyces on the serum levels of lipids and insulin, inflammation, and oxidative stress in patients with metabolic syndrome (MetS). Methods: Forty adult patients with MetS were randomly assigned to receive either 500 mg of H. sabdariffa calyx powder or placebo once daily for 4 weeks. Systolic and diastolic blood pressures (SBP and DBP) and BMI (body mass index) as well as fasting serum levels of glucose (FPG; fasting plasma glucose), insulin, lipoproteins, triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were determined pre-and post-intervention and compared. Results: H. sabdariffa significantly reduced serum TG (p=0.044) and SBP (p=0.049) compared to placebo. All other variables were not significantly affected by the interventions. Conclusions: Daily consumption of 500 mg of H. sabdariffa L. calyx powder can decrease SBP and serum TG in MetS patients. © 2016 by De Gruyter.
| Item Type: | Article |
|---|---|
| Keywords: | clinical trial Hibiscus sabdariffa L. hs-CRP lipid profile metabolic syndrome oxidative stress alanine aminotransferase aspartate aminotransferase C reactive protein glucose Hibiscus sabdariffa extract high sensitivity c reactive protein insulin lipid malonaldehyde placebo unclassified drug antioxidant plant medicinal product adult adult disease alanine aminotransferase blood level Article aspartate aminotransferase blood level body mass clinical article comparative study controlled study diastolic blood pressure diet restriction double blind procedure drug effect drug screening drug synthesis female glucose blood level Hibiscus sabdariffa human inflammation insulin blood level Iranian (citizen) kidney function test lipid blood level liver function test male metabolic syndrome X patient selection powder randomized controlled trial systolic blood pressure urea nitrogen blood level blood drug effects Hibiscus metabolism middle aged phytotherapy Antioxidants C-Reactive Protein Double-Blind Method Fasting Humans Lipids Plant Preparations |
| Page Range: | pp. 175-180 |
| Journal or Publication Title: | Journal of Complementary and Integrative Medicine |
| Journal Index: | Scopus |
| Volume: | 13 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.1515/jcim-2015-0030 |
| ISSN: | 15533840 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mui.ac.ir/id/eprint/4117 |
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