Modeling and Controlling TGF-beta Pathway Using Standard Petri Nets

Abstract

Cell growth is controlled by some factors known as growth factors. One of these growth factors is a substance called TGF-beta. Any malfunction in the system which growth factors perform in, results in drastic cell growth thus cell death. The aim of this study is to control the system of TGF-beta growth factor in the case of fibrosis, a condition created by malfunction in the pathway of TGF-beta. A model of TGF-beta pathway is proposed using standard Petri Nets. Then a control is proposed not only to control the amount of TGF-beta in the pathway but also to observe the law of conservation of matter as the absolute rule in biological systems. The results clearly show the control of TGF-beta concentration in the pathway. The research may provide a basis for drug design and determination of target reactants to control fibrosis.