The comparison of serum immunoglobulin G, M, E and A in the patients with oral lichen planus and oral lichenoid (Contact-drug) reaction

Abstract

Background: Oral lichenoid reaction is the general nomenclature for explanation of the lesions that have the same clinical and histological appearance. These reactions include lichen planus and oral lichenoid reactions lichenoid contact reaction, lichenoid drug eruption, and (graft-versus-host disease GVHD). This study tried to document the differences between these two groups lesions based on immunological criteria such as immunoglobulins (Ig) G, M, E and A. Methods: The method of this research was descriptive and analytic. The statistical samples included two groups of 25 patients who had lichen planus or lichenoid reactions differentiated from each other via clinical and histopathological criteria of World Health Organization (WHO). 5 cc of blood was taken from each patient. Then, all of the achieved data were analyzed using t and chi-square tests. Findings: The level of IgE increased in two groups, but there was not significant difference between oral lichen planus (OLP) and oral lichenoid reaction (OLR). The level of IgA was increased in oral lichen planus patients (P < 0.05). There were not significant differences between IgG and IgM in two groups. Conclusion: Suggestion of criteria for distinguishing oral lichen planus from oral lichenoid reaction is the first line for obtaining favorable treatment planning for all the patients. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.