Effects of Resvin supplement on the levels of interleukin-6 and C-reactive protein and insulin resistance in women with type 2 diabetes

Abstract

Background: Inflammation increases the complications of diabetes mellitus. Antioxidants can reduce inflammation. Interleukin-6 (IL-6) and C-reactive protein (CRP) are inflammatory factors, and the question is whether the Resvin, as an antioxidant, can reduce the levels of both and impact on insulin resistance? Methods: In this semi-experimental study, with pre-test and post-test design, 16 women with type 2 diabetes were randomly assigned to two equal groups of intervention (mean age: 59.25 ± 5.11 years) and control (mean age: 52.25 ± 10.60 years). Subjects in the intervention group received 400 mg of Resvin supplements daily for 6 weeks. Blood samples were taken for determination of IL-6 and CRP levels and the insulin resistance, before and after the intervention. Findings: After 6 weeks of receiving Resvin supplementation, CRP and IL-6 levels significantly decreased in the intervention group (P < 0.05). Insulin resistance improved significantly, too (P < 0.05). Conclusion: Based on the findings, Resvin supplementation may reduce the inflammatory markers and insulin resistance in women with type 2 diabetes. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.