Gabapentin, Pregabalin, and Placebo in Reducing Opioid Withdrawal Symptoms in Opioid-dependent Individuals: A Randomized-controlled Trial

(2018) Gabapentin, Pregabalin, and Placebo in Reducing Opioid Withdrawal Symptoms in Opioid-dependent Individuals: A Randomized-controlled Trial. Addictive Disorders & Their Treatment. pp. 55-64. ISSN 1531-5754

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Abstract

Objective: The objective of this study was to compare the efficacy of pregabalin and gabapentin in patients undergoing outpatient treatment for opiate withdrawal. Materials and Methods: In a 4-week double-blinded, randomized, placebo-controlled trial of pregabalin and gabapentin in buprenorphine-assisted detoxification (BAD) in the Specialized Addictive Behaviors Unit, an outpatient unit for the treatment of patients with an addictive disorder serving the city of Isfahan (Iran), 50 outpatients, 45 male individuals and 5 female individuals, aged 20 to 60 years, who met DSM-V criteria for opiate dependence, were randomly assigned to receive adjunctive treatment with either pregabalin (450mg/d), gabapentin (1600mg/d), or placebo under double-blinded conditions. The severity of subjective withdrawal symptoms were measured using the Short Opioid Withdrawal Scale (SOWS) at 5 stages. Results: Despite the effect of pregabalin and gabapentin on controlling some of the withdrawal symptoms, no significant differences were reported among the 3 groups. Conclusions: Dosages of 450mg/d of pregabalin and 1600mg/d of gabapentin are not significantly superior to placebo in controlling opiate withdrawal symptoms.

Item Type: Article
Keywords: gabapentin pregabalin opium dependence opioid withdrawal withdrawal symptoms opiate withdrawal detoxification abuse pain
Divisions: Behavioral Sciences Research Center
Faculty of Medicine > Departments of Clinical Sciences > Department of Psychiatric
Faculty of Health > Department of Epidemiology and Biostatistics
Page Range: pp. 55-64
Journal or Publication Title: Addictive Disorders & Their Treatment
Journal Index: ISI
Volume: 17
Number: 2
Identification Number: https://doi.org/10.1097/Adt.0000000000000127
ISSN: 1531-5754
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6721

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