Serum interleukin-18 and extent of coronary artery disease in unstable angina

(2018) Serum interleukin-18 and extent of coronary artery disease in unstable angina. Arya Atherosclerosis. pp. 122-127. ISSN 1735-3955

Full text not available from this repository.

Abstract

BACKGROUND: Interleukin-18 (IL-18) is an inflammatory marker with challenging role in atherosclerosis. The present study was carried out aiming to evaluate the association between IL-18 serum level and extent and severity of atherosclerosis among young patients with unstable angina (UA) who underwent coronary angiography. METHODS: This cross sectional study was performed from July to October 2015 in Chamran heart center, Isfahan, Iran. 180 patients with UA in the age range of below 50 years entered the study. All demographic, past history, physical examination, electrocardiogram (EKG or ECG), and transthoracic echocardiogram (TTE) data were collected. Serum level of IL-18 was measured using enzyme-linked immunosorbent assay (ELISA) method. A coronary angiography was performed on all patients to evaluate the presence and the incidence rate of coronary artery disease (CAD). RESULTS: Mean age of the patients was 46.0 +/- 4.6 years 47.4 +/- 4.3 and 45.9 +/- 4.9 among patients with CAD and normal coronary, respectively (P = 0.040). Rate of severe CAD was greater among men compared to women with values 67.8% and 51.8%, respectively (P = 0.032). The median interquartile range (IQR) value of serum IL-18 among patients with CAD 192.86 (128.03,325.75) was higher than normal coronary subjects 172.81 (139.77,243.21), however it was not significant (198.4 +/- 93.5, P = 0.287). A significant difference between serum IL-18 level and number of stenosis vessels was detected only among women (P = 0.032). CONCLUSION: Serum IL-18 level can predict the number of coronary arteries with significant stenosis among women with unstable angina.

Item Type: Article
Keywords: interleukin-18 unstable angina atherosclerosis angiography myocardial-infarction strong predictor isfahan cohort heart-disease inflammation atherosclerosis guidelines management severity protein
Divisions: Cardiovascular Research Institute > Cardiac Rehabilitation Research Center
Cardiovascular Research Institute > Heart Failure Research Center
Cardiovascular Research Institute > Hypertension Research Center
Cardiovascular Research Institute > Isfahan Cardiovascular Research Center
Page Range: pp. 122-127
Journal or Publication Title: Arya Atherosclerosis
Journal Index: ISI
Volume: 14
Number: 3
Identification Number: https://doi.org/10.22122/arya.v14i3.1370
ISSN: 1735-3955
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6899

Actions (login required)

View Item View Item