Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials

(2018) Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials. Hormone and Metabolic Research. pp. 227-235. ISSN 0018-5043

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Abstract

Type 2 diabetes mellitus (T2DM) is one of the most important public health issues. Vitamin K supplementation might have favorable effect on risk factors of T2DM. The aim of this study was to perform a systematic review and meta-analysis of interventional studies to examine the effect of vitamin K supplementation on glycemic indices. A systematic search was performed in electronic databases including PubMed, Science Direct, ProQuest, Institute of Scientific Information Web of Science, and Google scholar up to July 2017. We used a random effects model to estimate pooled effect size of fasting blood sugar (FBS), 2-h oral glucose tolerance test (2-h OGTT), fasting insulin (FINS), and homeostasis model assessment-estimated insulin resistance (HOMA-IR). Five clinical trials (533 participants) fulfilled the eligibility criteria of the present meta-analysis. Overall, meta-analysis could not show any beneficial effect of vitamin K supplementation on FBS (-0.91mg/dl, 95 CI: -2.57, 0.76, p=0.28), FINS (-0.35IU/ml, 95 CI: -1.70, 1.00, p=0.61), HOMA-IR (-0.06, 95 CI: -0.32, -0.19, p=0.63), and 2-h OGTT (-4.00mg/dl, 95 CI: -20.00, 11.99, p=0.62). Sensitivity analysis showed that overall estimates were not affected by elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, vitamin K supplementation had no significant effect on glycemic control in healthy subjects. However, further studies should be performed on diabetic and pre-diabetic patients to determine the effect of vitamin K supplementation on impaired glycemic control.

Item Type: Article
Keywords: vitamin k fasting blood sugar serum insulin glycemic control meta-analysis insulin-resistance dietary phylloquinone metabolic syndrome serum osteocalcin older men women risk adiponectin expression adults
Divisions: Food Security Research Center
School of Nutrition and Food Sciences > Department of Community Nutrition
School of Nutrition and Food Sciences > Student Research Committee
Page Range: pp. 227-235
Journal or Publication Title: Hormone and Metabolic Research
Journal Index: ISI
Volume: 50
Number: 3
Identification Number: https://doi.org/10.1055/s-0044-100616
ISSN: 0018-5043
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6950

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