Oligonucleotide aptamers: potential novel molecules against viral hepatitis

(2017) Oligonucleotide aptamers: potential novel molecules against viral hepatitis. Research in Pharmaceutical Sciences. pp. 88-98. ISSN 1735-5362

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Abstract

Viral hepatitis, as an international public health concern, seriously affects communities and health system. In recent years, great strides have been taken for development of new potential tools against viral hepatitis. Among these efforts, a valuable strategy introduced new molecules called "aptamers". Aptamers as potential alternatives for antibodies could be directed against any protein in infected cells and any components of viral particles. In this review, we will focus on recent advances in the diagnosis and treatment of viral hepatitis based on aptamer technology. In recent years, various types of aptamers including RNA and DNA were introduced against viral hepatitis. Some of these aptamers can be utilized for early and precise diagnosis of hepatitis infections and other group selected as therapeutic tools against viral targets. Designing diagnostic and therapeutic platforms based on aptamer technology is a promising approach in viral infections. The obtained aptamers in the recent years showed obvious potential for use as diagnostic and therapeutic tools against viral hepatitis. Although some modifications to increase the biostability and half-life of aptamers are underway, it seems these molecules will be a favorable substitute for monoclonal antibody in near future.

Item Type: Article
Keywords: dissolution rate nanocrystal nanoparticle nanosuspension nanosizing c virus-infection rna aptamers b-virus hepatocellular-carcinoma DNA aptamers hepg2.2.15 cells envelope protein surface-antigen apical loop hcv
Divisions: Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Faculty of Pharmacy and Pharmaceutical Sciences > گروه شیمی دارویی
Isfahan Pharmaceutical Sciences Research center
Page Range: pp. 88-98
Journal or Publication Title: Research in Pharmaceutical Sciences
Journal Index: ISI
Volume: 12
Number: 2
Identification Number: https://doi.org/10.4103/1735-5362.202447
ISSN: 1735-5362
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/718

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