Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials

(2018) Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research. pp. 2146-2154. ISSN 0951-418x

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Abstract

We performed a meta-analysis to evaluate the efficacy of cumin supplementation on plasma lipid concentration in adult population. The search included PubMed, Scopus, ISI Web of Science, Google Scholar, and the Cochrane library (up to January 2018) to identify randomized controlled trials (RCTs) investigating the effects of cumin supplementation on serum lipid parameters. Mean difference (MD) was pooled using a random-effects model. Meta-analysis of data from six eligible RCTs with 376 participants showed a significant reduction in plasma concentration of total cholesterol (MD 95% CI -10.90 -21.39, -0.42 mg/dl, p = 0.042) and low-density lipoprotein cholesterol (MD 95% CI -6.94 -11.53, -2.35 mg/dl, p = 0.003) after supplementation with cumin compared with control treatment, and plasma concentration of high-density lipoprotein cholesterol (MD 95% CI 3.35 1.58, 5.12 mg/dl, p<0.001) were found to be increased. Although our analysis indicated that cumin supplementation cannot change triglyceride (TG) concentration (MD 95% CI -20.48 -41.23, -0.26 mg/dl, p = 0.053), but after stratified the RCTs based on the primary level of TG (hypertriglyceridemia versus nonhypertriglyceridemia subjects), there was a significant decrease in nonhypertriglyceridemia subset. This systematic review and meta-analysis suggested the efficacy of cumin supplementation on lipid parameters.

Item Type: Article
Keywords: cumin lipids meta-analysis randomized controlled trials induced diabetic-rats clinical-trials blood-pressure cholesterol extract profile ginger hdl dyslipidemia overweight
Divisions: Food Security Research Center
School of Nutrition and Food Sciences > Department of Community Nutrition
School of Nutrition and Food Sciences > Student Research Committee
Page Range: pp. 2146-2154
Journal or Publication Title: Phytotherapy Research
Journal Index: ISI
Volume: 32
Number: 11
Identification Number: https://doi.org/10.1002/ptr.6162
ISSN: 0951-418x
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7363

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