(2018) Effect of Aerobic Exercise on Morphine Self-administration and Pain Modulation in Rats. Adv Biomed Res. p. 70. ISSN 2277-9175 (Print) 2277-9175 (Linking)
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Abstract
Background: Exercise reverses retention deficit induced by morphine. The present study investigated the effect of aerobic exercise on tolerance to morphine usage and pain modulation. Materials and Methods: Male Wistar rats were divided into four groups as follows: (1) saline group (S), (2) morphine group (M), (3) saline + exercise (S + E), and (4) morphine + exercise group (M + E). The rats were initially trained to receive small pellets of food by pressing an active lever in the self-administration apparatus. The tail-flick and hot-plate tests were used for pain assessment. To perform the experiment, the jugular vein was exposed and cannulated. After recovery, the animals were placed in the self-administration apparatus and allowed to self-administer morphine in 2 h sessions over 11 consecutive days. Results: The morphine group was found to record a higher number of active lever pressings than did the saline one while this parameter decreased in the morphine + exercise group compared with the morphine one. Moreover, the morphine + exercise exhibited lowered pain sensitivity as evidenced to have reduced morphine use in the hot plate test. Conclusion: The exercise might be suggested to reduce using of morphine and modulate pain probably through the release of endogenous opioid.
Item Type: | Article |
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Keywords: | Exercise morphine morphine self-administration pain rat |
Divisions: | Faculty of Medicine > Department of Basic Science > Department of Physiology |
Page Range: | p. 70 |
Journal or Publication Title: | Adv Biomed Res |
Journal Index: | Pubmed |
Volume: | 7 |
Identification Number: | https://doi.org/10.4103/abr.abr₁₈₁₁₇ |
ISSN: | 2277-9175 (Print) 2277-9175 (Linking) |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/7548 |
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