Effect of Aerobic Exercise on Morphine Self-administration and Pain Modulation in Rats

(2018) Effect of Aerobic Exercise on Morphine Self-administration and Pain Modulation in Rats. Adv Biomed Res. p. 70. ISSN 2277-9175 (Print) 2277-9175 (Linking)

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Abstract

Background: Exercise reverses retention deficit induced by morphine. The present study investigated the effect of aerobic exercise on tolerance to morphine usage and pain modulation. Materials and Methods: Male Wistar rats were divided into four groups as follows: (1) saline group (S), (2) morphine group (M), (3) saline + exercise (S + E), and (4) morphine + exercise group (M + E). The rats were initially trained to receive small pellets of food by pressing an active lever in the self-administration apparatus. The tail-flick and hot-plate tests were used for pain assessment. To perform the experiment, the jugular vein was exposed and cannulated. After recovery, the animals were placed in the self-administration apparatus and allowed to self-administer morphine in 2 h sessions over 11 consecutive days. Results: The morphine group was found to record a higher number of active lever pressings than did the saline one while this parameter decreased in the morphine + exercise group compared with the morphine one. Moreover, the morphine + exercise exhibited lowered pain sensitivity as evidenced to have reduced morphine use in the hot plate test. Conclusion: The exercise might be suggested to reduce using of morphine and modulate pain probably through the release of endogenous opioid.

Item Type: Article
Keywords: Exercise morphine morphine self-administration pain rat
Divisions: Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: p. 70
Journal or Publication Title: Adv Biomed Res
Journal Index: Pubmed
Volume: 7
Identification Number: https://doi.org/10.4103/abr.abr₁₈₁₁₇
ISSN: 2277-9175 (Print) 2277-9175 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7548

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