Are non-high-density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

(2018) Are non-high-density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study. Lipids Health Dis. p. 257. ISSN 1476-511X (Electronic) 1476-511X (Linking)

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Abstract

BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7-18 years. MetS was defined by the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group. The analysis of receiver operating characteristic (ROC) curve was applied to determine the optimal cut-points of non-HDL-C, difference between non-HDL-C and LDL-C (Diff-C) and triglycerides (TG) to HDL-C ratio (TG/HDL-C) for the prediction of MetS. RESULTS: Overall, the study participants consisted of 3843 students (52.3 boys) with mean (+/-SD) age of 12.28 (3.1) years. The odds of high LDL-C, low HDL-C and MetS were increased in subjects with higher non-HDL-C, Diff-C and TG/HDL-C (P < 0.05). Non-HDL-C, Diff-C and TG/HDL-C cut-off points for predicting MetS were 120.5 mg/dl (sensitivity: 44, specificity: 73), 19.9 mg/dl (sensitivity: 85, specificity: 75) and 2.53 (sensitivity: 82, specificity: 79), respectively. CONCLUSIONS: This study revealed a strong association between surrogates for serum lipid profile including non-HDL-C, TG/HDL-C and Diff-C and pediatric MetS. Our findings suggest that age- and gender-specific reference values of these markers were appropriate for both risk classification and long-term control of cardiovascular events in clinical assessments.

Item Type: Article
Keywords: Adolescents Children Metabolic syndrome Non-high-density lipoprotein cholesterol
Divisions: Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center
Page Range: p. 257
Journal or Publication Title: Lipids Health Dis
Journal Index: Pubmed
Volume: 17
Number: 1
Identification Number: https://doi.org/10.1186/s12944-018-0895-1
ISSN: 1476-511X (Electronic) 1476-511X (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7566

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