Preparation and in vitro evaluation of polycaprolactone/PEG/bioactive glass nanopowders nanocomposite membranes for GTR/GBR applications

(2018) Preparation and in vitro evaluation of polycaprolactone/PEG/bioactive glass nanopowders nanocomposite membranes for GTR/GBR applications. Mater Sci Eng C Mater Biol Appl. pp. 236-247. ISSN 1873-0191 (Electronic) 0928-4931 (Linking)

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Abstract

In the present study, nanocomposite membranes are investigated using poly-epsilon-caprolactone (PCL), polyethylene glycol (PEG) and bioactive glass nanopowders (BGs) synthesized via solvent casting method with different reinforcement rates of BGs consisting of 3, 5 and 7wt for regenerating the periodontal tissue in vitro. These prepared membranes were evaluated by a vast range of essential tests; including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Transmition-electron microscopy (TEM), tensile testing before and after soaking in PBS solution, degradation and contact angle assessments as well as cell culture assays. In spite of the fact that the percentage of Cu incorporated into BGs was trivial, this negligible amount exerted major cytotoxic impact upon cells during in vitro cell tests. According to the results, the blended-membrane contained 7wt copper-free BGs indicated optimum characteristics including satisfactory mechanical and biodegradation features, more wettable surface, higher proliferation rates of adipose-derived stem cells (ADSCs), superior ALP activity and brilliant bone mineralization capacity which was confirmed by Alizarin red assay. As a consequence, it can be used as a desirable candidate for guided tissue/bone regeneration (GTR/GBR) to accelerate bone tissue healing.

Item Type: Article
Keywords: Biocompatible Materials/chemistry Bone Regeneration/physiology Glass/*chemistry Guided Tissue Regeneration/methods Microscopy, Electron, Scanning Microscopy, Electron, Transmission Nanocomposites/*chemistry Polyesters/*chemistry Polyethylene Glycols/*chemistry Spectroscopy, Fourier Transform Infrared Bioactive glass nanoparticles Guided tissue/bone regeneration Nanocomposite membrane Polycaprolactone
Divisions: Biosensor research center
Page Range: pp. 236-247
Journal or Publication Title: Mater Sci Eng C Mater Biol Appl
Journal Index: Pubmed
Volume: 90
Identification Number: https://doi.org/10.1016/j.msec.2018.04.065
ISSN: 1873-0191 (Electronic) 0928-4931 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/8018

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