(2018) The effect of pomegranate extract on producing type ii collagen in differentiation of adipose-derived stem cells into chondrocytes. Journal of Isfahan Medical School. pp. 1540-1545. ISSN 10277595 (ISSN)
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Abstract
Background: Cartilage tissue is avascular and has no repairing capacity. For cartilage tissue engineering, stem cells and growth factors are used. In this study, the effect of pomegranate as inducer for chondrogenesis of adipose-derived stem cells (ADSCs) was evaluated. Methods: Human adipose-derived stem cells in third passage seeded in fibrin were cultured in chondrogenic medium with pomegranate for 2 weeks. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) and western blot technique were applied for evaluation of differentiated cells. Findings: Adipose-derived stem cells differentiated into chondrocytes; and type II collagen production by differentiated cells was proved. Conclusion: Pomegranate extract is an appropriate inducer for production of type II collagen in adipose-derived stem cells. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Chondrogenesis Pomegranate Stem cells Type II collagen |
| Divisions: | Faculty of Medicine > Department of Basic Science > Department of Anatomical Sciences Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy |
| Page Range: | pp. 1540-1545 |
| Journal or Publication Title: | Journal of Isfahan Medical School |
| Journal Index: | Scopus |
| Volume: | 35 |
| Number: | 453 |
| ISSN: | 10277595 (ISSN) |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/8194 |
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