Cancer risk among patients with multiple sclerosis: A cohort study in Isfahan, Iran

(2017) Cancer risk among patients with multiple sclerosis: A cohort study in Isfahan, Iran. Caspian Journal of Internal Medicine. pp. 172-177. ISSN 2008-6164

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Abstract

Background: Multiple sclerosis (MS), a central nervous system (CNS) autoimmune disorder, affects 2.3 million people around the world. Cancer kills around 7.5 million people annually. Both diseases have similar risks and intertwining molecular causes. Most studies focusing on MS and cancer have found an insignificant difference or reduction in the amount of cancer found in the MS community. Methods: We performed a cohort study using data from Isfahan Multiple Sclerosis Society (IMSS) and Isfahan cancer society and followed-up for 8 years on average (2006-2014). All of the 1718 MS patients were diagnosed according to McDonald's criteria, then standardized incidence ratio and the numbers of expected cancer case were calculated. Results: While patients had an insignificant change in cancer prevalence, men had fewer cancer cases and women showed an increased prevalence of cancer. Certain types of cancer proved statistically significant. Breast cancer, nervous system cancers, and lymphoma were elevated in the cohort. Conclusion: Our results support the hypothesis that MS significantly affects certain cancers in a protective or associative manner. All cancer rates, except breast cancer, cancers located in the nervous system, and lymphomas were reduced in cohort, suggesting that unregulated immune function may provide protective effects to MS patients against cancer.

Item Type: Article
Keywords: cancer multiple sclerosis cohort isfahan iran breast-cancer diagnostic-criteria
Divisions: Faculty of Medicine
Faculty of Medicine > Student Research Committee
Faculty of Medicine > Departments of Clinical Sciences > Department of Neurology
Page Range: pp. 172-177
Journal or Publication Title: Caspian Journal of Internal Medicine
Journal Index: ISI
Volume: 8
Number: 3
Identification Number: https://doi.org/10.22088/cjim.8.3.172
ISSN: 2008-6164
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/910

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