High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in in adult offspring

Abstract

Introduction: The salt diet during the pregnancy may disturb the adult offspring's organs functions. Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring. Materials and Methods: Renal IR was induced in 55 adult male and female offspring from mothers who intake high salt or normal drinking water during pregnancy, and the kidney function was evaluated. Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal IR gender dependently. Conclusion: The structural change in kidney of offspring from mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring's kidney functions after renal IR.