Oropharyngeal Irrigation to Prevent Ventilator-Associated-Pneumonia: Comparing Potassium Permangenate with Chlorhexidine

(2018) Oropharyngeal Irrigation to Prevent Ventilator-Associated-Pneumonia: Comparing Potassium Permangenate with Chlorhexidine. International Journal of Preventive Medicine. ISSN 2008-7802

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Abstract

Background: Pneumonia is one of the most common hospital-acquired infections among bedridden patients in Intensive Care Units (ICUs). Colonization of mouth and pharynx by pathogenic bacteria and their aspiration into the lower respiratory tract is an important step in pathogenesis of hospital-acquired pneumonia. The purpose of this study was to compare the effects of chlorhexidine and potassium permanganate mouthy/ashes in preventing incidence of hospital-acquired pneumonia in hospitalized patients in the ICU. Methods: This study is a clinical trial, conducted on 150 patients on ventilator in ICU. Patients were divided into three groups: Chlorhexidine group, potassium permanganate group, and control group. Mouthwashing three times a day, each time 5 min for 1 week by sterile gas with 10 cc solution of chlorhexidine, potassium permanganate, or placebo, was performed. Finally, pneumonia incidence was recorded, according to the Center for DiseAse Control and Prevention criteria. The data were analyzed by SPSS software version 20. Results: In the present study, 28 cases of pneumonia among 150 patients on ventilator were investigated. There were 15 (30), 6 (12), and 7 (14) incidences of pneumonia in control, chlorhexidine, and permanganate group, respectively. Pneumonia incidence in these groups differed significantly (P = 0.041). Conclusions: The use of common mouthwashes, especially chlorhexidine solution, for washing orophamix of ICU patients, can decrease pneumonia incidence, especially in patients under ventilation. Thus, washing and sterilizing mouth of patients with mouthwashes is recommended due to the high risk of hospital-acquired pneumonia in these patients.

Item Type: Article
Keywords: chlorhexidine pneumonia ventilator associated potassium permanganate intensive-care-unit infection
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Anesthesiology
Infectious Diseases and Tropical Medicine Research Center
Nosocomial Infection Research Center
Journal or Publication Title: International Journal of Preventive Medicine
Journal Index: ISI
Volume: 9
Identification Number: ARTN 93 10.4103/ijpvm.IJPVM₃₇₀₁₇
ISSN: 2008-7802
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/9824

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