Cornstarch-based wound dressing incorporated with hyaluronic acid and propolis: In vitro and in vivo studies

(2019) Cornstarch-based wound dressing incorporated with hyaluronic acid and propolis: In vitro and in vivo studies. Carbohydrate Polymers. pp. 25-35. ISSN 0144-8617

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Abstract

The unique physicochemical and functional characteristics of starch-based biomaterials and wound dressings have been proposed for several biomedical applications. Film dressings of cornstarch/hyaluronic acid/ethanolic extract of propolis (CS/HA/EEP) were prepared by solvent-casting and characterized by attenuated total reflectance/Fourier transform infrared spectroscopy, scanning electron microscopy, gas chromatography/mass spectrometry, light transmission, opacity measurements, EEP release, equilibrium swelling, and in vitro and in vivo evaluations. The CS/HA/0.5EEP film dressing exhibited higher antibacterial activity against Staphylococcus aureus (2.08 +/- 0.14 mm), Escherichia coli (2.64 +/- 0.18 mm), and Staphylococcus epidermidis (1.02 +/- 0.15 mm) in comparison with the CS, CS/HA, and CS/HA/0.25EEP films. Also, it showed no cytotoxicity for the L929 fibroblast cells. This wound dressing could effectively accelerate the wound healing process at Wistar rats' skin excisions. These results indicate that enrichment of cornstarch wound dressings with HA and EEP can significantly enhance their potential efficacy as wound dressing material.

Item Type: Article
Keywords: cornstarch hyaluronic acid propolis wound healing gelatin-based films ethanolic extract antimicrobial activity mechanical-properties physical-properties composite film red propolis corn starch skin wounds chitosan
Divisions: Biosensor research center
Cancer Prevention Research Center
Faculty of Health > Department of Environmental Health Engineering
Faculty of Medicine > Department of Basic Science > Department of Microbiology
School of Advanced Technologies in Medicine > Department of Biomaterials, Nanotechnology and Tissue Engineering
Page Range: pp. 25-35
Journal or Publication Title: Carbohydrate Polymers
Journal Index: ISI
Volume: 216
Identification Number: https://doi.org/10.1016/j.carbpol.2019.03.091
ISSN: 0144-8617
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/9944

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