(2019) Antispasmodic effect of hydroalcoholic extracts of rosemary and lavender on rat isolated uterus contractions. Journal of Isfahan Medical School. pp. 1136-1142. ISSN 10277595 (ISSN)
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Abstract
Background: In traditional medicine, Lavender and Rosemary are referred as antispasmodic agents. However, so far their direct effects on uterus contraction have not been reported. This study aimed to assess antispasmodic effect of hydroalcoholic extracts of rosemary and lavender on rat isolated uterus contractions. Methods: In this research, the relaxant effect of hydroalcoholic extracts of these plants on rat isolated uterus contraction induced by KCl, acetylcholine, oxytocin, and electrical field stimulation (EFS) was determined and compared with nifedipine. Findings: Hydroalcoholic extracts of Lavender and Rosemary inhibited uterus contractions induced by KCl, acetylcholine, oxytocin, and EFS in a concentration-dependent manner. Conclusion: Hydroalcoholic extracts of Lavender and Rosemary have relaxant effects on uterus smooth muscle, and can be useful in prevention of premature labor. © 2019 Isfahan University of Medical Sciences(IUMS). All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Lavender Rosemary plant Smooth muscle Uterus acetylcholine alcohol lavender extract nifedipine oxytocin plant extract potassium chloride Rosmarinus officinalis extract spasmolytic agent unclassified drug uterus spasmolytic agent animal experiment antispasmodic effect Article drug activity electric field electrostimulation myometrium nonhuman premature labor rat rosemary spasmolysis uterus contractility uterus contraction |
| Subjects: | QV Pharmacology |
| Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical Sciences > Department of Toxicology and Pharmacology |
| Page Range: | pp. 1136-1142 |
| Journal or Publication Title: | Journal of Isfahan Medical School |
| Journal Index: | Scopus |
| Volume: | 37 |
| Number: | 546 |
| Identification Number: | https://doi.org/10.22122/jims.v37i546.12312 |
| ISSN: | 10277595 (ISSN) |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/11958 |
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